Chlabicz S, Grzeszczuk A, Prokopowicz D
Department of Family Medicine and Community Nursing, Medical University of Białystok, ul. Mieszka I 4B, 15-054 Białystok, Poland.
J Hosp Infect. 2004 Nov;58(3):204-9. doi: 10.1016/j.jhin.2004.06.014.
Many hepatitis C virus (HCV)-infected individuals do not have any obvious risk factors and one of the putative sources of infection may be inadvertent exposure to infected blood or body fluids in the clinical setting. The aim of this study was to assess the role of medical procedures in transmission of hepatitis C in north-eastern Poland. In total, 194 patients with chronic hepatitis C were eligible for the study. The control group consisted of 275 age- and sex-matched individuals. Patients with a history of intravenous drug use were excluded. On multivariate analysis, transfusions [odds ratio (OR) = 3.7, 95% confidence interval (CI) 2.2-6.3], minor surgery (OR = 3.2, 95% CI 1.5-6.7) and dental care (OR = 2.3, 95% CI = 1.4-4.0) were independently associated with HCV infection. We conclude that apart from transfusion, minor medical procedures and dental care may carry a significant risk of hepatitis C infection. Improvements in basic hygiene routines and strict adherence to universal precautions may be essential to prevent iatrogenic transmission of the infection.
许多丙型肝炎病毒（HCV）感染者没有任何明显的危险因素，而一个可能的感染源可能是在临床环境中意外接触到受感染的血液或体液。本研究的目的是评估医疗程序在波兰东北部丙型肝炎传播中的作用。共有194例慢性丙型肝炎患者符合研究条件。对照组由275名年龄和性别匹配的个体组成。有静脉吸毒史的患者被排除在外。多因素分析显示，输血（比值比[OR]=3.7，95%置信区间[CI]2.2-6.3）、小手术（OR=3.2，95%CI 1.5-6.7）和牙科护理（OR=2.3，95%CI=1.4-4.0）与HCV感染独立相关。我们得出结论，除输血外，小型医疗程序和牙科护理可能具有丙型肝炎感染的重大风险。改善基本卫生习惯和严格遵守通用预防措施对于预防该感染的医源性传播可能至关重要。
