Chodniewicz David, Klemke Richard L
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Exp Cell Res. 2004 Nov 15;301(1):31-7. doi: 10.1016/j.yexcr.2004.08.006.
Cell migration requires establishment of a single pseudopodium in the direction of movement. Here we highlight recent advances in our understanding of the molecular signaling mechanisms that regulate formation of pseudopodia. We discuss how signal transduction processes are spatially and temporally organized to establish cell polarity through directed extension and stabilization of dominant pseudopodia. We also highlight recent advances in technology that will further the understanding of signaling dynamics specific to pseudopodia extension and cell migration.
细胞迁移需要在运动方向上形成单个伪足。在此，我们着重介绍了我们对调节伪足形成的分子信号传导机制理解的最新进展。我们讨论了信号转导过程如何在空间和时间上进行组织，以通过主导伪足的定向延伸和稳定来建立细胞极性。我们还强调了技术方面的最新进展，这些进展将进一步加深对伪足延伸和细胞迁移特有的信号动力学的理解。
