Department of Dental Technology and Materials Science, Central Taiwan University of Science and Technology, Taichung, Taiwan, ROC.
J Mater Sci Mater Med. 2013 Mar;24(3):645-57. doi: 10.1007/s10856-012-4843-8. Epub 2013 Jan 13.
Porous titanium and titanium alloys are promising scaffolds for bone tissue engineering, since they have the potential to provide new bone tissue ingrowth abilities and low elastic modulus to match that of natural bone. In the present study, porous Ti-7.5Mo alloy scaffolds with various porosities from 30 to 75 % were successfully prepared through a space-holder sintering method. The yield strength and elastic modulus of a Ti-7.5Mo scaffold with a porosity of 50 % are 127 MPa and 4.2 GPa, respectively, being relatively comparable to the reported mechanical properties of natural bone. In addition, the porous Ti-7.5Mo alloy exhibited improved apatite-forming abilities after pretreatment (with NaOH or NaOH + water) and subsequent immersion in simulated body fluid (SBF) at 37 °C. After soaking in an SBF solution for 21 days, a dense apatite layer covered the inner and outer surfaces of the pretreated porous Ti-7.5Mo substrates, thereby providing favorable bioactive conditions for bone bonding and growth. The preliminary cell culturing result revealed that the porous Ti-7.5Mo alloy supported cell attachment.
多孔钛及钛合金是很有前途的骨组织工程支架材料，因为它们具有提供新的骨组织向内生长能力和低弹性模量以匹配天然骨的潜力。在本研究中，通过占位烧结法成功制备了孔隙率为 30%至 75%的多孔 Ti-7.5Mo 合金支架。孔隙率为 50%的 Ti-7.5Mo 支架的屈服强度和弹性模量分别为 127MPa 和 4.2GPa，与天然骨的报道力学性能相当。此外，多孔 Ti-7.5Mo 合金在预处理（NaOH 或 NaOH+水）后和随后在 37°C 的模拟体液（SBF）中浸泡时表现出增强的磷灰石形成能力。在 SBF 溶液中浸泡 21 天后，预处理多孔 Ti-7.5Mo 基底的内外表面覆盖了致密的磷灰石层，从而为骨结合和生长提供了有利的生物活性条件。初步的细胞培养结果表明，多孔 Ti-7.5Mo 合金支持细胞附着。
