在加拿大，由产新型CTX-Mβ-内酰胺酶CTX-M-30的弗氏柠檬酸杆菌引起的社区发病疾病。
Community-onset disease caused by Citrobacter freundii producing a novel CTX-M beta-lactamase, CTX-M-30, in Canada.
作者信息
Abdalhamid Baha, Pitout Johann D D, Moland Ellen S, Hanson Nancy D
机构信息
Center for Research in Antiinfectives & Biotechnology, Department of Medical Microbiology and Immunology, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA.
出版信息
Antimicrob Agents Chemother. 2004 Nov;48(11):4435-7. doi: 10.1128/AAC.48.11.4435-4437.2004.
Abstract
Strains of Citrobacter freundii intermediate to cefotaxime but sensitive to ceftazidime were isolated from four different patients in Canada. Sequencing of PCR products by use of CTX-M-specific primers revealed a new combination of four amino acid substitutions. This new gene was designated bla(CTX-M-30) and was encoded on a 3-kb plasmid. The pI of CTX-M-30 was 8.0.
摘要
在加拿大，从四名不同患者中分离出了对头孢噻肟中度敏感但对头孢他啶敏感的弗氏柠檬酸杆菌菌株。使用CTX-M特异性引物对PCR产物进行测序，发现了四个氨基酸取代的新组合。这个新基因被命名为bla(CTX-M-30)，并由一个3kb的质粒编码。CTX-M-30的等电点为8.0。
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