Michels S, Schmidt-Erfurth U
University Eye Hospital, Lübeck, Germany.
Semin Ophthalmol. 2001 Dec;16(4):201-6. doi: 10.1076/soph.16.4.201.10298.
Photodynamic therapy (PDT) with verteporfin is a new treatment modality in ophthalmology that has previously shown its effectiveness in treatment of a variety of neoplastic pathologies. In this therapeutic approach, the photosensitizer verteporfin is activated by non-thermal laser light to obtain closure of neovascular structures. Preclinical and clinical studies have indicated that PDT is a safe, selective, and effective treatment for choroidal neovascularization in age-related macular degeneration. No significant damage to the neurosensory retina was found, which explains why PDT does not cause loss of visual acuity and may be used in a larger population than laser photocoagulation. This review summarizes the mechanisms of action of PDT, and the results of preclinical and clinical studies in ophthalmology.
维替泊芬光动力疗法（PDT）是眼科领域一种新的治疗方式，此前已在多种肿瘤性病变的治疗中显示出有效性。在这种治疗方法中，光敏剂维替泊芬通过非热激光激活，以实现新生血管结构的闭合。临床前和临床研究表明，PDT是治疗年龄相关性黄斑变性脉络膜新生血管的一种安全、选择性且有效的方法。未发现对神经感觉视网膜有明显损伤，这解释了为什么PDT不会导致视力丧失，并且可用于比激光光凝更大的人群。本综述总结了PDT的作用机制以及眼科临床前和临床研究的结果。
