Kilic-Okman Tulay, Guldiken Sibel, Kucuk Mustafa
Department of Obstetrics and Gynecology, Trakya University Faculty of Medicine, Edirne, Turkey.
Endocr J. 2004 Oct;51(5):505-8. doi: 10.1507/endocrj.51.505.
Hyperhomocysteinemia is a risk factor for atherosclerotic vascular diseases. It is known that plasma homocysteine levels are higher in polycystic ovary syndrome (PCOS) patients than in healthy subjects. The aim of our study was to determine the relationship between plasma homocysteine level and insulin resistance in women with PCOS. Twenty-nine patients (age, 23.90 +/- 5.86 years) and twenty-five healthy subjects (age, 25.24 +/- 4.28 years) were involved in the study. Plasma levels of fasting insulin, glucose, homocysteine, FSH, and LH levels were measured. A statistically significant difference in plasma concentrations of HOMA index, homocysteine, basal insulin levels and LH/FSH ratios was observed between groups (P = 0.001, P = 0.001, P = 0.001, and P = 0.01, respectively). There was no relationship between Hcy and the other variables. In multiple logistic regression analysis, age, BMI and insulin resistance were not predictors of Hcy.
高同型半胱氨酸血症是动脉粥样硬化性血管疾病的一个危险因素。已知多囊卵巢综合征（PCOS）患者的血浆同型半胱氨酸水平高于健康受试者。我们研究的目的是确定PCOS女性患者血浆同型半胱氨酸水平与胰岛素抵抗之间的关系。29例患者（年龄23.90±5.86岁）和25名健康受试者（年龄25.24±4.28岁）参与了该研究。测量了空腹胰岛素、血糖、同型半胱氨酸、促卵泡激素（FSH）和促黄体生成素（LH）的血浆水平。两组之间在稳态模型评估（HOMA）指数、同型半胱氨酸、基础胰岛素水平和LH/FSH比值的血浆浓度上观察到统计学上的显著差异（分别为P = 0.001、P = 0.001、P = 0.001和P = 0.01）。同型半胱氨酸与其他变量之间没有关系。在多因素逻辑回归分析中，年龄、体重指数（BMI）和胰岛素抵抗不是同型半胱氨酸的预测因素。
