Yilmaz Nafiye, Pektas Mine, Tonguc Esra, Kilic Sevtap, Gulerman Cavidan, Gungor Tayfun, Mollamahmutoglu Leyla
Department of Infertility, Dr Zekai Tahir Burak Women's Health Research and Education Hospital, Ankara, Turkey.
J Obstet Gynaecol Res. 2008 Jun;34(3):384-91. doi: 10.1111/j.1447-0756.2007.00699.x.
This study aims to investigate the existence of any relationship between homocysteine levels and insulin resistance in Turkish women with polycystic ovary syndrome.
A case-controlled, cross-sectional, observational study was undertaken in a total of 94 infertile Turkish women who required professional help in the Department of Infertility of Dr Zekai Tahir Burak Women's Health Research and Education Hospital. The correlation between serum homocysteine with age, body mass index, hormone profile, fasting insulin and glucose concentrations and insulin resistance were examined in patients with polycystic ovary syndrome and the results were compared to those of women with normal ovaries, who served as a control group.
The mean serum fasting glucose and insulin levels, thus insulin resistance index of women with polycystic ovary syndrome, were significantly higher than those of the control subjects. The mean serum homocysteine levels were significantly higher in women with polycystic ovary syndrome than those in the control group. A positive correlation was detected between the mean homocysteine, the insulin resistance index determined by homeostasis model assessment and the fasting insulin levels in polycystic ovary syndrome patients.
Serum homocysteine levels are elevated in women with polycystic ovary syndrome, and this elevation is associated with the serum insulin level rather than androgen excess. The intense treatment of hyperhomocysteinemia in women with polycystic ovary syndrome might improve reproductive outcome and contribute to protection from cardiovascular risks.
本研究旨在调查患有多囊卵巢综合征的土耳其女性中，同型半胱氨酸水平与胰岛素抵抗之间是否存在任何关联。
在泽凯·塔希尔·布拉克妇女健康研究与教育医院不孕症科，对总共94名需要专业帮助的不孕土耳其女性进行了一项病例对照、横断面观察性研究。检测了多囊卵巢综合征患者血清同型半胱氨酸与年龄、体重指数、激素谱、空腹胰岛素和血糖浓度以及胰岛素抵抗之间的相关性，并将结果与作为对照组的卵巢正常女性的结果进行比较。
多囊卵巢综合征女性的平均血清空腹血糖和胰岛素水平，以及胰岛素抵抗指数，均显著高于对照组。多囊卵巢综合征女性的平均血清同型半胱氨酸水平显著高于对照组。在多囊卵巢综合征患者中，平均同型半胱氨酸、通过稳态模型评估确定的胰岛素抵抗指数与空腹胰岛素水平之间存在正相关。
多囊卵巢综合征女性的血清同型半胱氨酸水平升高，且这种升高与血清胰岛素水平相关，而非雄激素过多。对多囊卵巢综合征女性的高同型半胱氨酸血症进行强化治疗，可能会改善生殖结局，并有助于预防心血管风险。
