Kedar-Barnes Inbal, Rozen Paul
Department of Medical Genetics, Rabin Medical Center, Beilinson Campus, Petach Tikva, Israel.
Fam Cancer. 2004;3(3-4):193-9. doi: 10.1007/s10689-004-9544-0.
The Jews are an ancient and unique group of people linked by language, religion and customs in spite of their major geographical shifts, expulsions, forced conversions and massacres throughout their entire history. As a result of these historical events that led to repeated migration, the Jewish people became dispersed into various ethnic sub-groups. Between these ethnic groups exists heterogeneity, as well as some similarities, to the populations amongst whom they lived. Rare genetic diseases have been reported to be prevalent among the different groups of Jews, which for the most part can be explained by random genetic drift together with intra-familial marriages. In this publication, we will briefly discuss the origin of the various ethnic groups and some of the genetic diseases commonly found in them, with emphasis on the Ashkenazim, their prevalent genetic diseases and cancer susceptibility.
犹太人是一个古老而独特的群体，尽管在其整个历史中经历了重大的地理变迁、驱逐、强迫改宗和大屠杀，但他们通过语言、宗教和习俗联系在一起。由于这些导致反复迁徙的历史事件，犹太人散居到了各个不同的族群中。这些族群之间存在异质性，同时与他们所生活的人群也有一些相似之处。据报道，罕见遗传病在不同的犹太人群体中普遍存在，在很大程度上这可以通过随机遗传漂变以及家族内通婚来解释。在本出版物中，我们将简要讨论各个族群的起源以及其中一些常见的遗传病，重点关注阿什肯纳兹犹太人、他们普遍的遗传病和癌症易感性。
