Butt T, Ahmad R N, Kazmi S Y, Rafi N
Department of Microbiology, Armed Forces Institute of Pathology, Rawalpindi.
J Pak Med Assoc. 2004 Sep;54(9):469-72.
To determine the resistance pattern of Mycobacterium tuberculosis isolates in Rawalpindi-Islamabad.
The study was carried out at the Department of Microbiology, Armed Forces Institute of Pathology, Rawalpindi between September 2000 and August 2002. We examined 1359 pulmonary and extra-pulmonary specimens from suspected cases of tuberculosis. The radiometric Bactec 460 TB system was used for culture and antimicrobial susceptibility testing.
Mycobacterium tuberculosis was isolated from 325 clinical specimens. Antimicrobial susceptibility of the isolates was tested against the four first-line anti-tuberculous drugs (rifampicin, isoniazid, streptomycin and ethambutol). Fifteen percent of the isolates were resistant to a single drug, 28% were multi-drug resistant including 7% which were resistant to all the four drugs. The overall resistance against individual drugs was rifampicin 32%, isoniazid 37%, streptomycin 19% and ethambutol 17%.
The increasing level of drug resistance among mycobacterial isolates in our population is most alarming. Strict implementation of control measures is required to combat this unfolding crisis.
确定拉瓦尔品第 - 伊斯兰堡地区结核分枝杆菌分离株的耐药模式。
该研究于2000年9月至2002年8月在拉瓦尔品第武装部队病理研究所微生物学系开展。我们检查了1359份来自疑似结核病病例的肺部和肺外标本。采用放射性Bactec 460 TB系统进行培养和药敏试验。
从325份临床标本中分离出结核分枝杆菌。对分离株进行了针对四种一线抗结核药物（利福平、异烟肼、链霉素和乙胺丁醇）的药敏试验。15%的分离株对单一药物耐药，28%为多重耐药，其中7%对所有四种药物均耐药。各药物的总体耐药率分别为：利福平32%、异烟肼37%、链霉素19%、乙胺丁醇17%。
我国人群中分枝杆菌分离株的耐药水平不断上升，令人极为担忧。需要严格实施控制措施来应对这一日益严重的危机。
