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溶血、肝酶升高和血小板减少综合征的诊断与管理

Diagnosis and management of hemolysis, elevated liver enzymes, and low platelets syndrome.

作者信息

Barton John R, Sibai Baha M

机构信息

Central Baptist Hospital, Perinatal Diagnostic Center, 1740 Nicholasville Road, Lexington, KY 40503-1499, USA.

出版信息

Clin Perinatol. 2004 Dec;31(4):807-33, vii. doi: 10.1016/j.clp.2004.06.008.

DOI:10.1016/j.clp.2004.06.008
PMID:15519429
Abstract

Pregnancies complicated by hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome require a well-formulated management plan. The development of this syndrome after 34 weeks' gestation or with documentation of maternal or fetal compromise is an indication for delivery. Acute fatty liver of pregnancy, hemolytic uremic syndrome, and thrombotic thrombocytopenic purpura may present with signs, symptoms, and laboratory abnormalities that may be confused with HELLP syndrome. Thorough investigation is warranted because of the differences in proper management among these various complications of pregnancy. Expectant management in patients with HELLP syndrome remote from term and the use of corticosteroids to improve postpartum maternal outcome remain experimental.

摘要

妊娠合并溶血、肝酶升高和血小板减少(HELLP)综合征需要制定完善的管理计划。妊娠34周后出现该综合征或有母体或胎儿受损的记录是分娩的指征。妊娠急性脂肪肝、溶血性尿毒症综合征和血栓性血小板减少性紫癜可能表现出与HELLP综合征相混淆的体征、症状和实验室异常。由于这些不同的妊娠并发症在恰当管理方面存在差异,因此有必要进行全面调查。对孕周尚早的HELLP综合征患者进行期待治疗以及使用糖皮质激素来改善产后母体结局仍处于试验阶段。

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