Esposito S, Noviello S, Leone S, Tice A, Seibold G, Nathwani D, Scaglione F
Department of Infectious Diseases, University of Naples, Ospedale Gesù e Maria, Via Cotugno 1, 80135 Naples, Italy.
Int J Antimicrob Agents. 2004 Nov;24(5):473-8. doi: 10.1016/j.ijantimicag.2004.06.004.
In order to assess how outpatient parenteral antibiotic therapy (OPAT) is managed in different countries, we analyzed the data collected in the USA, UK and Italy by the International OPAT Registry using an ad hoc Access/Excel Microsoft program. The analysis of data concerned 9826 patients in the USA, 981 in the UK and 620 in Italy. Differences were observed in several aspects of OPAT management such as the infections treated and the antibiotics utilized. The duration of therapy also differed: it was much longer in Italy (56.0 average days), than in the USA (22.5 days) and UK (19.9 days). Delivery model, delivery route and infusion devices show substantial differences. The present analysis shows that OPAT is carried out with substantial differences in different countries probably according to different programmes and guidelines adopted.
为评估不同国家门诊胃肠外抗生素治疗（OPAT）的管理情况，我们使用专门的Microsoft Access/Excel程序，分析了国际OPAT注册中心在美国、英国和意大利收集的数据。数据分析涉及美国的9826例患者、英国的981例患者和意大利的620例患者。在OPAT管理的几个方面观察到差异，如治疗的感染类型和使用的抗生素。治疗持续时间也有所不同：意大利（平均56.0天）比美国（22.5天）和英国（19.9天）长得多。给药模式、给药途径和输液装置存在显著差异。目前的分析表明，不同国家开展OPAT时可能根据所采用的不同方案和指南存在显著差异。
