Yong E L, Glasier A, Hillier H, Ledger W, Caird L, Beattie G, Sweeting V, Thong J, Baird D T
Department of Obstetrics and Gynaecology, University of Edinburgh, UK.
Hum Reprod. 1992 Jan;7(1):39-43. doi: 10.1093/oxfordjournals.humrep.a137553.
Cyclofenil is a triphenylethylene derivative, similar in structure to clomiphene citrate, which is used to induce ovulation in anovulatory women. The effects of cyclofenil on a group of 10 normal cyclic and 10 oligomenorrhoeic subjects were examined in a double blind controlled cross-over study. Both groups of women were administered either cyclofenil or, following a washout cycle, a placebo in two treatment cycles. Urinary oestrone and pregnanediol excretion were measured daily and ultrasound scans performed to assess follicular development. Frequent sampling of blood was performed on day 6 to study luteinizing hormone (LH) and follicle stimulating hormone (FSH) pulsatile release. Cervical mucus changes and sperm-cervical mucus interaction were studied after identification of the LH peak. There were no significant differences between cyclofenil and placebo cycles in the following: ovulation rates, daily urinary oestrone and pregnanediol excretion, the number or size of developing follicles, LH pulsatility (parameters studied: number of peaks, pulse interval, pulse amplitude, pulse area and mean nadir LH), mean FSH level on day 6, cervical mucus and sperm-cervical mucus interaction. In view of our inability to demonstrate an effect on any parameter of endocrine function in normal and oligomenorrhoeic women, these results throw doubt on the therapeutic value of cyclofenil in its present dosage and formulation.
环苯吩嗪是一种三苯乙烯衍生物，其结构与枸橼酸氯米芬相似，用于诱导无排卵女性排卵。在一项双盲对照交叉研究中，研究了环苯吩嗪对一组10名正常月经周期女性和10名月经过少女性的影响。两组女性在两个治疗周期中分别服用环苯吩嗪，或在洗脱期后服用安慰剂。每天测量尿雌酮和孕二醇排泄量，并进行超声扫描以评估卵泡发育。在第6天频繁采集血液样本，以研究促黄体生成素（LH）和促卵泡生成素（FSH）的脉冲式释放。在确定LH峰值后，研究宫颈黏液变化以及精子与宫颈黏液的相互作用。在以下方面，环苯吩嗪周期和安慰剂周期之间没有显著差异：排卵率、每日尿雌酮和孕二醇排泄量、发育卵泡的数量或大小、LH脉冲性（研究参数：峰值数量、脉冲间隔、脉冲幅度、脉冲面积和平均最低LH）、第6天的平均FSH水平、宫颈黏液以及精子与宫颈黏液的相互作用。鉴于我们无法证明环苯吩嗪对正常和月经过少女性的任何内分泌功能参数有影响，这些结果使人对环苯吩嗪目前剂量和剂型的治疗价值产生怀疑。
