Varma T R, Patel R H, Pillai U
Department of Obstetrics & Gynaecology, St. George's Hospital Medical School, London, U.K.
Int J Gynaecol Obstet. 1988 Oct;27(2):231-8. doi: 10.1016/0020-7292(88)90013-6.
Graafian follicle growth was studied by ultrasound scanning during the peri-ovulatory period in 64 ovulatory cycles in 32 infertile patients on cyclofenil treatment, and compared with a control group of 32 patients with confirmed ovulatory cycles assessed on the basis of serum progesterone levels in the middle of the second half of the cycle. The mean maximum diameters of the leading follicles before ovulation were 21.9 +/- 0.6 (S.E.) mm and 24.4 +/- 0.5 (S.E.) mm, respectively for the cyclofenil group and the normal control group (P greater than 0.05). In 79% of the cyclofenil stimulated group and 83% of the spontaneous ovulation group, ultrasonic evidence of ovulation was present between 12 and 36 h after the initial increase in urine LH levels. Ultrasound scanning was found to be simple, and a quick method of monitoring graafian follicle development and ovulation on cyclofenil therapy and the cycles were comparable to the spontaneous ovulatory cycles as assessed on the basis of graafian follicle diameter, and the time of ovulation. Cervical score was not found to be useful to assess ovulation time in the cyclofenil treated group since 31.3% achieved a score of 10 or more on day -4, 93.8% within 24 h of ovulation and 24% on day 3 following the ovulation.
对32例接受氯底酚胺治疗的不育患者的64个排卵周期在围排卵期通过超声扫描研究了格拉夫卵泡的生长情况，并与根据周期后半期血清孕酮水平评估确定有排卵周期的32例患者的对照组进行了比较。氯底酚胺组和正常对照组排卵前优势卵泡的平均最大直径分别为21.9±0.6（标准误）mm和24.4±0.5（标准误）mm（P>0.05）。在氯底酚胺刺激组的79%和自然排卵组的83%中，在尿促黄体生成素水平最初升高后的12至36小时之间有排卵的超声证据。发现超声扫描是一种简单且快速的方法，可用于监测氯底酚胺治疗时格拉夫卵泡的发育和排卵情况，并且这些周期与根据格拉夫卵泡直径和排卵时间评估的自然排卵周期相当。在氯底酚胺治疗组中，宫颈评分对评估排卵时间无用，因为31.3%在-4天宫颈评分为10分或更高，93.8%在排卵后24小时内达到该评分，24%在排卵后第3天达到该评分。
