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CD8+抑制性T细胞的Qa-1限制

Qa-1 restriction of CD8+ suppressor T cells.

作者信息

Sarantopoulos Stefanie, Lu Linrong, Cantor Harvey

机构信息

Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA.

出版信息

J Clin Invest. 2004 Nov;114(9):1218-21. doi: 10.1172/JCI23152.

DOI:10.1172/JCI23152
PMID:15520850
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC524234/
Abstract

There is increasing evidence that the immune response can be inhibited by several T cell subsets, including NK T cells, CD25+CD4+ T cells, and a subpopulation of CD8+ T cells. Animal model studies of multiple sclerosis have suggested an important role for suppressor CD8+ T cells in protection against disease recurrence and exacerbation. The molecular lynchpin of CD8+ suppressive activity is the murine MHC molecule Qa-1, termed HLA-E in humans. Here we summarize findings from work on Qa-1 that have begun to delineate suppressor CD8+ T cells and their mechanisms of action in the context of self tolerance and autoimmune disease.

摘要

越来越多的证据表明，免疫反应可被包括自然杀伤T细胞、CD25 + CD4 + T细胞和CD8 + T细胞亚群在内的多种T细胞亚群抑制。多发性硬化症的动物模型研究表明，抑制性CD8 + T细胞在预防疾病复发和加重方面发挥着重要作用。CD8 + 抑制活性的分子关键是小鼠MHC分子Qa-1，在人类中称为HLA-E。在这里，我们总结了关于Qa-1的研究结果，这些研究开始在自身耐受和自身免疫性疾病的背景下描绘抑制性CD8 + T细胞及其作用机制。

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2
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本文引用的文献

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An integrated model of immunoregulation mediated by regulatory T cell subsets.由调节性T细胞亚群介导的免疫调节整合模型。
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Analysis of regulatory CD8 T cells in Qa-1-deficient mice.Qa-1缺陷小鼠中调节性CD8 T细胞的分析。
Nat Immunol. 2004 May;5(5):516-23. doi: 10.1038/ni1063. Epub 2004 Apr 18.
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Suppression of autoimmune disease after vaccination with autoreactive T cells that express Qa-1 peptide complexes.用表达Qa-1肽复合物的自身反应性T细胞进行疫苗接种后自身免疫疾病的抑制。
J Clin Invest. 2004 Apr;113(8):1218-24. doi: 10.1172/JCI20772.
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Control of immune homeostasis by naturally arising regulatory CD4+ T cells.自然产生的调节性CD4+ T细胞对免疫稳态的调控。
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Regulatory CD8+ T cells fine-tune the myelin basic protein-reactive T cell receptor V beta repertoire during experimental autoimmune encephalomyelitis.调节性CD8 + T细胞在实验性自身免疫性脑脊髓炎期间微调髓鞘碱性蛋白反应性T细胞受体Vβ库。
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A peptide from heat shock protein 60 is the dominant peptide bound to Qa-1 in the absence of the MHC class Ia leader sequence peptide Qdm.在缺乏MHC I类a型前导序列肽Qdm的情况下，热休克蛋白60的一种肽是与Qa-1结合的主要肽。
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Preferential escape of subdominant CD8+ T cells during negative selection results in an altered antiviral T cell hierarchy.阴性选择过程中优势不明显的CD8+ T细胞优先逃逸，导致抗病毒T细胞层级结构改变。
J Immunol. 2003 Feb 1;170(3):1231-9. doi: 10.4049/jimmunol.170.3.1231.
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DNA vaccination with heat shock protein 60 inhibits cyclophosphamide-accelerated diabetes.用热休克蛋白60进行DNA疫苗接种可抑制环磷酰胺加速型糖尿病。
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Inhibition of adjuvant arthritis by a DNA vaccine encoding human heat shock protein 60.编码人热休克蛋白60的DNA疫苗对佐剂性关节炎的抑制作用
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