通过根管对经格罗斯曼根管封闭剂改变的犬牙髓组织的细胞介导免疫反应。
Cell-mediated immune response to dog pulp tissue altered by Grossman's formula sealer via the root canal.
作者信息
Block R M, Lewis R D, Sheats J B, Fawley J
出版信息
Oral Surg Oral Med Oral Pathol. 1979 Apr;47(4):372-7. doi: 10.1016/0030-4220(79)90263-9.
Pulp tissue from three experimental dogs was tested for its antigenicity before and after incubation with Grossman's formula sealer (GS). Cellmediated skin-test reactions showed an increased response to pulp that had been incubated in Grossman's formula sealer, washed, and then injected as compared with pulp or GS alone. In vitro analysis of cell-mediated immune response (lymphocyte proliferation) showed a marked increase when pulp tissue was incubated in GS and washed as compared to saline-treated pulp. Comparing the saline-incubated pulp to the GS-altered pulp revealed that the increase in radioactivity was statistically significant at p less than 0.0001. Therefore, Grossman's formula sealer altered dog pulp tissue and rendered it antigenically active, and a specific cell-mediated lymphocyte response was produced.
对三只实验犬的牙髓组织在与格罗斯曼配方封闭剂（GS）孵育前后进行了抗原性测试。细胞介导的皮肤试验反应显示，与单独的牙髓或GS相比，在格罗斯曼配方封闭剂中孵育、洗涤后再注射的牙髓的反应有所增加。细胞介导免疫反应（淋巴细胞增殖）的体外分析表明，与用盐水处理的牙髓相比，牙髓组织在GS中孵育并洗涤后，淋巴细胞增殖显著增加。将用盐水孵育的牙髓与经GS改变的牙髓进行比较，发现放射性增加在统计学上具有显著意义，p值小于0.0001。因此，格罗斯曼配方封闭剂改变了犬牙髓组织并使其具有抗原活性，从而产生了特异性的细胞介导淋巴细胞反应。
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