Kang J S, Pilkington J D, Ferguson D, Kim H K, Romsos D R
Department of Food Science and Human Nutrition, Michigan State University, East Lansing 48824-1224.
J Nutr. 1992 Apr;122(4):895-905. doi: 10.1093/jn/122.4.895.
The body energy balance response of ob/ob mice to adrenalectomy is diet dependent. Diets varying in source of carbohydrate (starch, glucose or fructose), fat to starch ratio, or fat to glucose ratio were fed to determine influences on energy balance in female adrenalectomized ob/ob mice. Adrenalectomy lowered food intake in all ob/ob mice to values comparable to those of lean mice independent of diet, but the percentage of dietary energy retained as body energy in adrenalectomized ob/ob mice was lowered to values comparable to those of lean mice only in mice fed starch or fructose, not in mice fed glucose or fat. Consumption of either high glucose or high fat diets blocked about one-half the overall effect of adrenalectomy on energy balance in ob/ob mice. Hyperinsulinemia was associated with the high efficiency of energy retention observed in adrenalectomized ob/ob mice fed glucose, but high efficiency of energy retention occurred in adrenalectomized ob/ob mice fed high fat diets without concomitant hyperinsulinemia. Adrenalectomy-induced changes in brain weight and protein content, body protein content and plasma thyroid hormone concentrations in ob/ob mice were independent of diet consumption. Combined adrenalectomy-ovariectomy diminished, but did not eliminate, the diet-dependent influences on energy balance in ob/ob mice. In conclusion, dietary glucose and dietary fat both attenuate effects of adrenalectomy on energy balance in ob/ob mice by promoting high efficiencies of energy retention.
ob/ob小鼠对肾上腺切除术的身体能量平衡反应取决于饮食。给雌性肾上腺切除的ob/ob小鼠喂食碳水化合物来源（淀粉、葡萄糖或果糖）、脂肪与淀粉比例或脂肪与葡萄糖比例不同的饮食，以确定对能量平衡的影响。肾上腺切除术使所有ob/ob小鼠的食物摄入量降低到与瘦小鼠相当的值，且与饮食无关，但仅在喂食淀粉或果糖的小鼠中，肾上腺切除的ob/ob小鼠中作为身体能量保留的膳食能量百分比降低到与瘦小鼠相当的值，而在喂食葡萄糖或脂肪的小鼠中则没有。食用高糖或高脂肪饮食会阻断肾上腺切除术对ob/ob小鼠能量平衡的约一半总体影响。高胰岛素血症与喂食葡萄糖的肾上腺切除的ob/ob小鼠中观察到的高能量保留效率相关，但在喂食高脂肪饮食的肾上腺切除的ob/ob小鼠中也出现了高能量保留效率，且没有伴随高胰岛素血症。肾上腺切除术引起的ob/ob小鼠脑重量和蛋白质含量、身体蛋白质含量和血浆甲状腺激素浓度的变化与饮食消耗无关。联合肾上腺切除术-卵巢切除术减少了，但并未消除，对ob/ob小鼠能量平衡的饮食依赖性影响。总之，膳食葡萄糖和膳食脂肪都通过促进高能量保留效率来减弱肾上腺切除术对ob/ob小鼠能量平衡的影响。
