Warwick B P, Romsos D R
Department of Food Science and Human Nutrition, Michigan State University, East Lansing 48824-1224.
Am J Physiol. 1988 Jul;255(1 Pt 2):R141-8. doi: 10.1152/ajpregu.1988.255.1.R141.
Effects of different carbohydrate types on energy balance, fatty acid synthesis, and plasma insulin concentrations in adrenalectomized ob/ob mice were investigated. Obese (ob/ob) and lean mice adrenalectomized at 4 wk of age received one of four high-carbohydrate powdered diets for 3 wk: stock, glucose, starch, or starch plus wheat bran. Adrenalectomy reduced energy intake of ob/ob mice equally independent of diet type, whereas energetic efficiency, in vivo rates of fatty acid synthesis in liver and white adipose tissue, and plasma insulin concentrations were substantially reduced to approach values in lean mice in all adrenalectomized ob/ob mice except those fed glucose. The ability of adrenalectomy to normalize energy balance in ob/ob mice depends on factors other than the reduced circulating concentration of glucocorticoids alone. Diet composition is a crucial factor, and striking differences exist between semipurified diets containing a simple sugar (glucose) and those containing a complex carbohydrate (starch), with no additional effect of dietary fiber (wheat bran).
研究了不同碳水化合物类型对肾上腺切除的ob/ob小鼠能量平衡、脂肪酸合成及血浆胰岛素浓度的影响。4周龄时接受肾上腺切除的肥胖（ob/ob）和瘦小鼠，给予四种高碳水化合物粉状饲料之一，持续3周：基础饲料、葡萄糖、淀粉或淀粉加麦麸。肾上腺切除同等程度地降低了ob/ob小鼠的能量摄入，与饲料类型无关，而除喂食葡萄糖的小鼠外，所有肾上腺切除的ob/ob小鼠的能量效率、肝脏和白色脂肪组织中脂肪酸的体内合成率以及血浆胰岛素浓度均大幅降低，接近瘦小鼠的值。肾上腺切除使ob/ob小鼠能量平衡正常化的能力取决于除糖皮质激素循环浓度降低之外的其他因素。饮食组成是一个关键因素，含单糖（葡萄糖）的半纯化饲料和含复合碳水化合物（淀粉）的半纯化饲料之间存在显著差异，膳食纤维（麦麸）无额外影响。
