毛萼晶V，一种从毛萼香茶菜（Dunn.）原田分离得到的具有新型C19骨架的细胞毒性二萜类化合物。
Maoecrystal V, cytotoxic diterpenoid with a novel C19 skeleton from Isodon eriocalyx (Dunn.) hara.
作者信息
Li Sheng-Hong, Wang Jia, Niu Xue-Mei, Shen Yun-Heng, Zhang Hong-Jie, Sun Han-Dong, Li Ma-Lin, Tian Qin-E, Lu Yang, Cao Peng, Zheng Qi-Tai
机构信息
Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, P. R. China.
出版信息
Org Lett. 2004 Nov 11;6(23):4327-30. doi: 10.1021/ol0481535.
Maoecrystal V (1), a novel C(19) diterpenoid possessing a unique 6,7-seco-6-nor-15(8-->9)-abeo-5,8-epoxy-ent-kaurane skeleton, was isolated from the leaves of a Chinese medicinal herb, Isodon eriocalyx. Its structure was determined by comprehensive NMR and MS spectroscopic analysis and confirmed by single-crystal X-ray diffraction study. Compound 1 showed remarkable inhibitory activity toward HeLa cells with IC(50) = 0.02 microg/mL (cis-platin: IC(50) = 0.99 microg/mL).
毛萼晶V（1）是一种新型的C(19)二萜类化合物，具有独特的6,7-开环-6-降-15(8→9)-去甲-5,8-环氧-对映-贝壳杉烷骨架，从一种中国草药毛萼香茶菜的叶子中分离得到。其结构通过综合核磁共振和质谱光谱分析确定，并经单晶X射线衍射研究证实。化合物1对HeLa细胞显示出显著的抑制活性，IC(50) = 0.02微克/毫升（顺铂：IC(50) = 0.99微克/毫升）。
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