Qiu S X, Sun H D, Lobkovsky E, Chai H, Clardy J, Farnsworth N R, Pezzuto J M, Fong H H
College of Pharmacy, University of Illinois at Chicago, USA.
Planta Med. 1998 Dec;64(8):728-31. doi: 10.1055/s-2006-957567.
From the leaves of Isodon megathyrsus, a novel ent-kaurene diterpene, megathyrin B, was isolated and its structure determined as 1 alpha,7 beta,11 beta,15 beta-tetrahydroxy-ent-7 alpha,20-epoxy-kaur-16-ene by 1D- and 2D-NMR spectral analysis. Additionally, its stereochemistry was unambiguously assigned by X-ray crystallography. This compound was cytotoxic to the KB and KB-V cell lines.
从大锥香茶菜（Isodon megathyrsus）的叶子中分离出一种新型的对映-贝壳杉烯二萜——大锥香茶菜素B，并通过一维和二维核磁共振光谱分析确定其结构为1α,7β,11β,15β-四羟基-对映-7α,20-环氧-贝壳杉-16-烯。此外，通过X射线晶体学明确确定了其立体化学结构。该化合物对KB和KB-V细胞系具有细胞毒性。
