Han Quan-Bin, Cheung Susan, Tai Joseph, Qiao Chun-Feng, Song Jing-Zheng, Tso Ting-Fai, Sun Han-Dong, Xu Hong-Xi
Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong, P. R. China.
Org Lett. 2006 Oct 12;8(21):4727-30. doi: 10.1021/ol061757j.
[structure: see text] A novel diterpene with an unprecedented tetracyclic 6,7:8,15-di-seco-7,20-olide-6,8-cyclo-ent-kaurane skeleton, named maoecrystal Z (1), has been isolated from the leaves of a Chinese medicinal herb, Isodon eriocalyx (Labiatae). Its structure was determined by comprehensive NMR and MS spectroscopic analysis coupled with single-crystal X-ray crystallographic diffraction. Compound 1 exhibited comparable inhibitory effect against human K562 leukemia, MCF7 breast, and A2780 ovarian tumor cells with IC(50) = 2.90, 1.63, and 1.45 microg/mL and with camptothecin and paclitaxel as the positive controls.
[结构：见正文] 从一种中国药用植物毛萼香茶菜（唇形科）的叶子中分离出一种具有前所未有的四环6,7:8,15-二断-7,20-内酯-6,8-环-对映-贝壳杉烷骨架的新型二萜，命名为毛萼晶Z（1）。通过综合核磁共振和质谱光谱分析以及单晶X射线晶体学衍射确定了其结构。以喜树碱和紫杉醇作为阳性对照，化合物1对人K562白血病细胞、MCF7乳腺癌细胞和A2780卵巢肿瘤细胞表现出相当的抑制作用，IC(50)分别为2.90、1.63和1.45微克/毫升。
