用于醛巴豆酰化反应的高非对映选择性和对映选择性试剂。
Highly diastereo- and enantioselective reagents for aldehyde crotylation.
作者信息
Hackman Blaine M, Lombardi Pamela J, Leighton James L
机构信息
Department of Chemistry, Columbia University, New York, New York 10027, USA.
出版信息
Org Lett. 2004 Nov 11;6(23):4375-7. doi: 10.1021/ol0480731.
PMID:15524487
Abstract
Two new, crystalline solid, storable, and highly enantioselective reagents for aldehyde crotylation have been developed. Both (cis and trans) crotylsilane reagents are easily prepared in bulk, require trivial reaction conditions, and provide the homoallylic alcohol products with near diastereo- and enantiospecificity in many cases.
摘要
已经开发出两种新型的、结晶性固体、可储存且对醛的巴豆酰化具有高对映选择性的试剂。两种（顺式和反式）巴豆基硅烷试剂都易于大量制备，反应条件简单，并且在许多情况下能以接近非对映和对映特异性的方式提供高烯丙基醇产物。
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