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2

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Asymmetric allyl- and crotylboration with the robust, versatile, and recyclable 10-TMS-9-borabicyclo[3.3.2]decanes.使用坚固、通用且可回收的10-三甲基硅基-9-硼双环[3.3.2]癸烷进行不对称烯丙基硼化和巴豆基硼化反应。

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一种更全面、更实用的对映选择性醛烯丙基化方法。 - Suppr | 超能文献

一种更全面、更实用的对映选择性醛烯丙基化方法。

A more comprehensive and highly practical solution to enantioselective aldehyde crotylation.

机构信息

Department of Chemistry, Columbia University, New York, New York 10027, USA.

出版信息

J Am Chem Soc. 2011 May 4;133(17):6517-20. doi: 10.1021/ja200712f. Epub 2011 Apr 12.

DOI:10.1021/ja200712f

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3090146/

Abstract

The enantioselective crotylation of aldehydes with 1,2-diaminochlorocrotylsilane reagents is effectively catalyzed by Sc(OTf)(3). The one significant limitation on the utility of these reagents--substrate scope--has thus been addressed. The net result is the most comprehensive and highly practical method for enantioselective aldehyde crotylation yet advanced.

摘要

手性烯丙基硅试剂与醛的对映选择性 crotylation 反应可有效地被 Sc(OTf)(3) 催化。这些试剂的一个显著的局限性——底物范围——因此得到了解决。最终得到了迄今为止最全面和最实用的对映选择性醛 crotylation 方法。

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