Lee Stephanie A, Raad Issam I, Adachi Javier A, Han Xiang Y
Section of Infectious Diseases, The University of Texas M. D. Anderson Cancer Center, Houston 77030, Texas 77030, USA
J Clin Microbiol. 2004 Nov;42(11):5429-31. doi: 10.1128/JCM.42.11.5429-5431.2004.
Mycobacterium brumae is a rapidly growing environmental mycobacterial species identified in 1993; so far, no infections by this organism have been reported. Here we present a catheter-related M. brumae bloodstream infection in a 54-year-old woman with breast cancer. The patient presented with high fever (39.7 degrees C), and >1,000 colonies of M. brumae grew from a quantitative culture of blood drawn through the catheter. A paired peripheral blood culture was negative, however, suggesting circulational control of the infection. The patient was treated empirically with meropenem and vancomycin, and the fever resolved within 24 h. The catheter was removed a week later, and from the tip M. brumae was isolated a second time, suggesting catheter colonization. The organism was identified by colonial morphology, sequence analysis of the 16S rRNA gene, and biochemical tests.
布鲁氏分枝杆菌是1993年发现的一种快速生长的环境分枝杆菌；迄今为止，尚未有该菌感染的报道。在此，我们报告一例54岁乳腺癌女性患者发生的与导管相关的布鲁氏分枝杆菌血流感染。患者出现高热（39.7摄氏度），通过导管抽取的血液定量培养长出>1000个布鲁氏分枝杆菌菌落。然而，配对的外周血培养为阴性，提示感染处于循环控制状态。患者接受美罗培南和万古霉素经验性治疗，发热在24小时内消退。一周后拔除导管，导管尖端再次分离出布鲁氏分枝杆菌，提示导管定植。通过菌落形态、16S rRNA基因序列分析和生化试验鉴定该菌。
