Oh Won Sup, Ko Kwan Soo, Song Jae-Hoon, Lee Mi Young, Ryu Seong Yeol, Taek Sang, Kwon Ki Tae, Lee Jang-Ho, Peck Kyong Ran, Lee Nam Yong
Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
BMC Infect Dis. 2005 Nov 25;5:107. doi: 10.1186/1471-2334-5-107.
Rapidly growing mycobacteria is recognized as one of the causative agents of catheter-related infections, especially in immunocompromised hosts. To date, however, Mycobacterium senegalense, which was known as the principal pathogen of bovine farcy, has not been reported in human infection.
We describe the first case of human infection by M. senegalense, which has caused catheter-related bloodstream infection in a cancer patient in Korea. The microorganism was identified by the 16S rRNA gene, rpoB, and 16S-23S rRNA gene internal transcribed spacer (ITS) sequence analyses.
Our first report of catheter-associated bacteremia caused by M. senegalense suggests the zoonotic nature of this species and indicates the expansion of mycobacterial species relating to human infection. M. senegalense should be considered as one of the causes of human infections in the clinical practice.
快速生长分枝杆菌被认为是导管相关感染的病原体之一，尤其是在免疫功能低下的宿主中。然而，迄今为止，曾被认为是牛皮肤鼻疽主要病原体的塞内加尔分枝杆菌尚未见人类感染的报道。
我们描述了首例由塞内加尔分枝杆菌引起的人类感染病例，该病例导致韩国一名癌症患者发生导管相关血流感染。通过16S rRNA基因、rpoB基因以及16S-23S rRNA基因内部转录间隔区（ITS）序列分析鉴定出该微生物。
我们关于塞内加尔分枝杆菌引起导管相关菌血症的首例报告提示了该菌种的人畜共患性质，并表明与人类感染相关的分枝杆菌种类有所增加。在临床实践中，应将塞内加尔分枝杆菌视为人类感染的病因之一。
