Hawkins Claudia, Qi Chao, Warren John, Stosor Valentina
Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Diagn Microbiol Infect Dis. 2008 Jun;61(2):187-91. doi: 10.1016/j.diagmicrobio.2008.01.004. Epub 2008 Feb 21.
Rapidly growing nontuberculous mycobacteria (RGMs) are responsible for a variety of clinical syndromes in humans including catheter-related blood stream infections (CRBSIs). Recently, we identified a cluster of RGM-associated CRBSI at our institution. We describe the epidemiologic and clinical patterns associated with these infections. We conducted a retrospective single-center review of RGM CRBSI between May 2004 and June 2005. RGMs isolated from blood cultures of 6 patients included Mycobacterium mucogenicum (2), Mycobacterium fortuitum (2), and the rare RGM species, Mycobacterium neoaurum (1) and Mycobacterium septicum (1). All of the patients had a long-term intravascular catheter (mean duration, 6.5 months). Bacteremia was resolved in all patients after catheter removal and appropriate antibiotics. None of the patients suffered a relapse of RGM CRBSI, and all survived to 1 year. RGMs are causative pathogens in both immunosuppressed and immunocompetent individuals with long-term intravascular catheters and blood stream infections. Recent trends at our center suggest that infections with these pathogens are rising.
快速生长非结核分枝杆菌（RGMs）可导致人类多种临床综合征，包括导管相关血流感染（CRBSIs）。最近，我们在本机构发现了一组与RGM相关的CRBSI。我们描述了与这些感染相关的流行病学和临床模式。我们对2004年5月至2005年6月期间的RGM CRBSI进行了回顾性单中心研究。从6例患者血培养中分离出的RGM包括产黏液分枝杆菌（2例）、偶然分枝杆菌（2例）以及罕见的RGM菌种新金色分枝杆菌（1例）和腐败分枝杆菌（1例）。所有患者均有长期血管内导管（平均使用时长6.5个月）。拔除导管并使用适当抗生素后，所有患者的菌血症均得到缓解。所有患者均未出现RGM CRBSI复发，且均存活至1年。RGMs是长期血管内导管和血流感染的免疫抑制及免疫功能正常个体的致病病原体。我们中心的近期趋势表明，这些病原体感染呈上升趋势。
