Goto S, Saito Y, Shiiba K, Matsuno S
First Department of Surgery, Tohoku University School of Medicine, Sendai, Japan.
Nihon Geka Gakkai Zasshi. 1994 Jul;95(7):435-41.
We investigated the correlation between venous invasion and hematogenous metastasis in gastric cancer. In 70 patients with gastric cancer, 8 cases had hepatic metastasis at operation (group A), 26 cases were identified with hematogenous recurrence after operation (group B) and 36 cases were disease free over 5 years after operation (group C). Specimens were all step-sectioned and serial sections were stained both with HE and EM. Rates of venous invasion were calculated as following formulae; (number of cancer involving veins/total number of veins investigated) x 100 (%). Results were as follows. 1. Average rates of venous invasion (ARVI) of groups A and B were significantly higher than that of group C (A; 7.6%, B; 2.6%, C; 0.7% p < 0.05). 2. In subserosal or serosal layer, there is no significant difference between ARVI of group A and that of group B. 3. No significant difference was seen between group A and B in rates of venous invasion to larger vein (diameter > 200 microns). These observations suggest that cancer invasion to the veins located in deeper than subserosal layer or ranged in diameter over 200 microns relates to hematogenous metastasis.
我们研究了胃癌中静脉侵犯与血行转移之间的相关性。在70例胃癌患者中，8例在手术时有肝转移（A组），26例术后出现血行复发（B组），36例术后5年无疾病复发（C组）。所有标本均进行连续切片，连续切片分别用苏木精-伊红（HE）染色和电子显微镜（EM）染色。静脉侵犯率按以下公式计算：（累及静脉的癌灶数/所检查的静脉总数）×100（%）。结果如下：1. A组和B组的平均静脉侵犯率（ARVI）显著高于C组（A组：7.6%，B组：2.6%，C组：0.7%，p<0.05）。2. 在浆膜下层或浆膜层，A组和B组的ARVI之间无显著差异。3. A组和B组在侵犯较大静脉（直径>200微米）的静脉侵犯率方面无显著差异。这些观察结果表明，癌灶侵犯位于浆膜下层以下或直径超过200微米的静脉与血行转移有关。
