Lussi A, Jaeggi T, Gerber C, Megert B
Department of Operative, Preventive and Paediatric Dentistry, University of Bern, School of Dental Medicine, Bern, Switzerland.
Caries Res. 2004 Nov-Dec;38(6):567-71. doi: 10.1159/000080588.
The aim of this study was to test the effect of fluoride rinsing on the prevention of toothbrush abrasion of softened enamel in situ. For softening, the samples were immersed in 0.1 M citric acid (pH 3.5) for 3 min. Eight test subjects had to make 5 runs in which 4 slabs per run were attached to intraoral appliances. They were as follows: (1) no softening, no fluoride rinsing (control 1); (2) softening, no fluoride rinsing (control 2); (3) softening, rinsing in situ with a sodium/amine fluoride rinsing solution (250 ppm F) for 30 s; (4) rinsing in situ with the sodium/amine fluoride rinsing solution (250 ppm F) for 30 s, softening; (5) softening, rinsing in situ with an experimental amine fluoride-containing rinsing solution (250 ppm F) for 30 s. After exposure for 60 min to the oral milieu, the volunteers brushed the samples for 30 s with toothpaste and the loss of tooth substance was determined. For each test person, the secretion rate of resting and paraffin-stimulated saliva, buffering capacity and pH were measured. Toothbrush abrasion in situ was not significantly lower using the fluoride rinsing solutions before or after softening the enamel compared to no rinsing (p > 0.05). Multiple linear regression analyses revealed that 57% of the variation in toothbrush abrasion could be attributed to the severity of softening (p < 0.001) and the pH of stimulated saliva (p < 0.001). It was concluded that a single rinse for 30 s had no statistically significant effect on the prevention of toothbrush abrasion of softened enamel.
本研究的目的是测试含氟漱口水对原位预防软化牙釉质牙刷磨损的效果。为使牙釉质软化，将样本浸入0.1M柠檬酸（pH 3.5）中3分钟。八名测试对象需进行5次操作，每次操作将4个样本块固定在口腔矫治器上。操作如下：（1）未软化，未用含氟漱口水漱口（对照1）；（2）软化，未用含氟漱口水漱口（对照2）；（3）软化，用氟化钠/胺漱口水（250ppm F）原位漱口30秒；（4）用氟化钠/胺漱口水（250ppm F）原位漱口30秒，然后软化；（5）软化，用含实验性胺氟化物的漱口水（250ppm F）原位漱口30秒。在暴露于口腔环境60分钟后，志愿者用牙膏刷牙30秒，并测定牙质损失量。对每位测试者，测量静息和石蜡刺激唾液的分泌率、缓冲能力和pH值。与未漱口相比，在牙釉质软化前后使用含氟漱口水原位刷牙磨损率并无显著降低（p>0.05）。多元线性回归分析显示，57%的牙刷磨损变化可归因于软化程度（p<0.001）和刺激唾液的pH值（p<0.001）。研究得出结论，单次30秒漱口对预防软化牙釉质的牙刷磨损无统计学显著效果。
