Changkakoti Liza, Rajabalaya Rajan, David Sheba R, Balaraman Ashok Kumar, Sivasubramanian Hemalatha, Mukherjee Ashis K, Bala Asis
Pharmacology and Drug Discovery Research Laboratory, Division of Life Sciences; Institute of Advanced Study in Science and Technology (IASST), Vigyan Path, Guwahati, PIN-781035, Assam, India.
Academy of Scientific and Innovative Research (AcSIR), AcSIR (an Indian Institute of National Importance), Sector 19, Kamla Nehru Nagar, Ghaziabad, Uttar Pradesh PIN-201002, India.
Curr Neuropharmacol. 2025;23(5):547-563. doi: 10.2174/011570159X327677240902105443.
Neurodegenerative diseases (NDDs) are a multifaceted and heterogeneous group of complex diseases. Unfortunately, a cure for these conditions has yet to be found, but there are ways to reduce the risk of developing them. Studies have shown that specific vitamins regulate the brain molecules and signaling pathways, which may help prevent degeneration. This review focuses on examining the role of vitamins in preventing five significant types of neurodegenerative diseases, including Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD), Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). This review also highlights promising and controversial findings about the potential impact of vitamins on this group of diseases. Several developed countries standardize daily dietary vitamin intake to meet nutrient requirements, improve health, and prevent chronic diseases like NDDs. However, more research is necessary to gain a more comprehensive understanding of their therapeutic benefits, including studies exploring different drug-dose paradigms, diverse humanized animal models, and clinical trials conducted in various locations.
神经退行性疾病（NDDs）是一类复杂的、多方面且异质性的疾病。不幸的是，目前尚未找到治愈这些疾病的方法，但有办法降低患这些疾病的风险。研究表明，特定的维生素可调节大脑分子和信号通路，这可能有助于预防神经退行性变。本综述重点探讨维生素在预防五种主要类型神经退行性疾病中的作用，包括帕金森病（PD）、阿尔茨海默病（AD）、亨廷顿病（HD）、多发性硬化症（MS）和肌萎缩侧索硬化症（ALS）。本综述还强调了关于维生素对这类疾病潜在影响的有前景和有争议的发现。一些发达国家对日常饮食中的维生素摄入量进行规范，以满足营养需求、改善健康状况并预防如NDDs等慢性疾病。然而，有必要进行更多研究，以更全面地了解其治疗益处，包括探索不同药物剂量模式、多种人源化动物模型以及在不同地点开展的临床试验的研究。
