Hanson C Jane, Bootman Martin D, Roderick H Llewelyn
Calcium Group, Laboratory of Molecular Signalling, Babraham Institute, Babraham, Cambridge CB2 4AT, UK.
Curr Biol. 2004 Nov 9;14(21):R933-5. doi: 10.1016/j.cub.2004.10.019.
There is substantial evidence that Ca2+ fluxes occur during most forms of apoptosis, and that inhibiting such fluxes protects cells from death. IP3 receptors--ligand-gated channels that release Ca2+ from intracellular stores--are emerging as key sites for regulation by pro- and anti-apoptotic factors.
有大量证据表明，在大多数形式的细胞凋亡过程中都会发生钙离子通量变化，并且抑制这种通量变化可保护细胞免于死亡。肌醇三磷酸受体——从细胞内储存库释放钙离子的配体门控通道——正逐渐成为促凋亡和抗凋亡因子进行调控的关键位点。
