Siemiatycki Jack, Richardson Lesley, Straif Kurt, Latreille Benoit, Lakhani Ramzan, Campbell Sally, Rousseau Marie-Claude, Boffetta Paolo
Département de Médecine sociale et préventive, Université de Montréal, Montréal, Québec, Canada.
Environ Health Perspect. 2004 Nov;112(15):1447-59. doi: 10.1289/ehp.7047.
The occupational environment has been a most fruitful one for investigating the etiology of human cancer. Many recognized human carcinogens are occupational carcinogens. There is a large volume of epidemiologic and experimental data concerning cancer risks in different work environments. It is important to synthesize this information for both scientific and public health purposes. Various organizations and individuals have published lists of occupational carcinogens. However, such lists have been limited by unclear criteria for which recognized carcinogens should be considered occupational carcinogens, and by inconsistent and incomplete information on the occupations and industries in which the carcinogenic substances may be found and on their target sites of cancer. Based largely on the evaluations published by the International Agency for Research on Cancer, and augmented with additional information, the present article represents an attempt to summarize, in tabular form, current knowledge on occupational carcinogens, the occupations and industries in which they are found, and their target organs. We have considered 28 agents as definite occupational carcinogens, 27 agents as probable occupational carcinogens, and 113 agents as possible occupational carcinogens. These tables should be useful for regulatory or preventive purposes and for scientific purposes in research priority setting and in understanding carcinogenesis.
职业环境一直是研究人类癌症病因的一个成果丰硕的领域。许多已确认的人类致癌物都是职业致癌物。有大量关于不同工作环境中癌症风险的流行病学和实验数据。为了科学和公共卫生目的,综合这些信息很重要。各种组织和个人都公布了职业致癌物清单。然而,这些清单受到限制,一方面对于哪些已确认的致癌物应被视为职业致癌物的标准不明确,另一方面关于可能发现致癌物质的职业和行业以及它们的癌症靶器官的信息不一致且不完整。本文主要基于国际癌症研究机构发表的评估,并补充了其他信息,试图以表格形式总结关于职业致癌物、发现它们的职业和行业以及它们的靶器官的现有知识。我们将28种物质视为确定的职业致癌物,27种物质视为很可能的职业致癌物,113种物质视为可能的职业致癌物。这些表格对于监管或预防目的以及在研究优先级设定和理解致癌作用的科学目的方面应该是有用的。
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