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基于大规模随机人群研究的戒烟干预。Inter99研究。

Smoking cessation intervention in a large randomised population-based study. The Inter99 study.

作者信息

Pisinger Charlotta, Vestbo Jørgen, Borch-Johnsen Knut, Jørgensen Torben

机构信息

Research Centre for Prevention and Health, Nordre Ringvej, DK-2600 Glostrup University Hospital, Glostrup, Denmark.

出版信息

Prev Med. 2005 Mar;40(3):285-92. doi: 10.1016/j.ypmed.2004.06.001.

Abstract

BACKGROUND

Several large and well-conducted community interventions have failed to detect an effect on prevalence of smoking.

METHODS

Two thousand four hundred eight daily smokers in all motivational stages were actively recruited and included in a randomised population-based intervention study in Copenhagen, Denmark. All smokers completed a questionnaire and underwent a health examination and a lifestyle consultation. Daily smokers in the high intensity intervention group were offered assistance to quit in smoking cessation groups.

RESULTS

The validated abstinence rate at 1-year follow-up was 16.3% in the high intensity group and 12.7% in the low intensity group compared with a self-reported abstinence rate of 7.3% in the background population. The adjusted odds ratio of abstinence in the high intervention group was significantly higher, OR = 2.2 (1.6-3.0) than in the background population, also in the 'intention-to-treat' analyses, OR = 1.5 (1.1-2.0). Higher socioeconomic status, higher age at onset of daily smoking, and a higher wish to quit were predictors of success.

CONCLUSION

In a population-based setting, using active recruitment and offering assistance to quit, it was possible to include many smokers and to achieve a significantly higher validated abstinence in the high intensity intervention than in the background population, even when using 'intention-to-treat' analyses.

摘要

背景

多项大型且实施良好的社区干预未能发现对吸烟流行率有影响。

方法

积极招募了处于所有动机阶段的2408名每日吸烟者,并将其纳入丹麦哥本哈根一项基于人群的随机干预研究。所有吸烟者均完成一份问卷,并接受健康检查和生活方式咨询。高强度干预组的每日吸烟者在戒烟小组中获得戒烟帮助。

结果

高强度组1年随访时经验证的戒烟率为16.3%,低强度组为12.7%,而背景人群自我报告的戒烟率为7.3%。在“意向性分析”中,高强度干预组戒烟的调整优势比显著高于背景人群,比值比(OR)=2.2(1.6 - 3.0),在“意向性分析”中OR = 1.5(1.1 - 2.0)。较高的社会经济地位、开始每日吸烟时较高的年龄以及较高的戒烟意愿是成功的预测因素。

结论

在基于人群的环境中,通过积极招募并提供戒烟帮助,即使采用“意向性分析”,也有可能纳入许多吸烟者,并使高强度干预组经验证的戒烟率显著高于背景人群。

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