Krishna Sanjeev, Uhlemann Anne-Catrin, Haynes Richard K
Department of Cellular and Molecular Medicine, Infectious Diseases, St. George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK.
Drug Resist Updat. 2004 Aug-Oct;7(4-5):233-44. doi: 10.1016/j.drup.2004.07.001.
Artemisinins form the most important class of antimalarial currently available, particularly because they are effective against parasites resistant to almost all the other classes. Their mechanism of action is controversial. Some aspects of this controversy are reviewed here. Whilst there is no clinical resistance yet identified to artemisinins, the potential to examine the relationship between polymorphisms in PfATP6 (a target of artemisinins) in multidrug resistant isolates of Plasmodium falciparum, is also discussed.
青蒿素是目前最重要的一类抗疟药物，特别是因为它们对几乎所有其他类别的抗药寄生虫都有效。它们的作用机制存在争议。本文回顾了这一争议的一些方面。虽然尚未发现对青蒿素的临床耐药性，但也讨论了研究恶性疟原虫多药耐药分离株中PfATP6（青蒿素的一个靶点）多态性之间关系的可能性。
