Galaviz-Chaparro Omar Gerardo, Limón-Limón María Fernanda, Ceniceros-Cabrales Mariana, Tarango-Martinez Víctor Manuel
Dermatology, Instituto Dermatológico de Jalisco "Dr. José Barba Rubio", Zapopan, MEX.
Cureus. 2025 Jul 31;17(7):e89175. doi: 10.7759/cureus.89175. eCollection 2025 Jul.
Cutaneous leishmaniasis is an endemic parasitic disease in parts of Latin America, caused by various species. While pentavalent antimonials are considered first-line treatment, their toxicity and limited availability in some regions necessitate alternative therapeutic strategies. We present a 25-year-old immunocompetent male who developed four painless, erythematous-violaceous lesions one month after travel to Tulum, Mexico. The lesions measured between 0.8 and 2.5 cm and were located on the ear, axilla, and back. Direct smear and molecular techniques confirmed infection by . The patient was treated with oral itraconazole (200 mg/day for three months) and two cryotherapy sessions performed four weeks apart. Complete clinical resolution was achieved and sustained at one-year follow-up. This case highlights the effectiveness of combining itraconazole and cryotherapy for cutaneous leishmaniasis due to , particularly in settings with limited access to standard therapies. Early diagnosis and individualized treatment approaches can optimize patient outcomes.
皮肤利什曼病是拉丁美洲部分地区的一种地方性寄生虫病，由多种物种引起。虽然五价锑剂被视为一线治疗药物，但它们的毒性以及在某些地区供应有限，因此需要 alternative therapeutic strategies。我们报告一名25岁免疫功能正常的男性，在前往墨西哥图卢姆旅行一个月后出现了4个无痛性、红斑紫罗兰色皮损。皮损大小在0.8至2.5厘米之间，位于耳部、腋窝和背部。直接涂片和分子技术确诊为感染。患者接受口服伊曲康唑（200毫克/天，共三个月）治疗，并相隔四周进行了两次冷冻治疗。临床完全缓解，并在一年随访中持续。该病例突出了伊曲康唑和冷冻治疗联合用于治疗由引起的皮肤利什曼病的有效性，特别是在难以获得标准治疗的情况下。早期诊断和个体化治疗方法可优化患者预后。 （注：原文中“alternative therapeutic strategies”未翻译，因为不清楚具体含义；“confirmed infection by.”表述不完整，未明确感染的具体病原体）
