Gozes Illana, Furman Sharon
Department of Clinical Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
Best Pract Res Clin Endocrinol Metab. 2004 Dec;18(4):623-40. doi: 10.1016/j.beem.2004.08.006.
Neuropeptides are expressed in neurons innervating endocrine cells or in endocrine cells and cancer cells, and are released on site to act as hormones and growth factors. Vasoactive intestinal peptide (VIP) was first discovered in the early 1970s and has since become the area of research for many laboratories. VIP has a neuroendocrine role as it is intimately involved with the synthesis, secretion and action of other neuroendocrine hormones as well as cytokines and chemokines. Major outcomes of VIP downregulation encompass developmental and behavioral dysfunctions, including impaired diurnal rhythms. Overexpression of VIP has been associated with diarrhea and cancer, and overexpression of VIP receptors is associated with cancerous growth. This short review outlines some of the recent progress made in VIP research.
神经肽在支配内分泌细胞的神经元中表达，或在内分泌细胞和癌细胞中表达，并在局部释放，充当激素和生长因子。血管活性肠肽（VIP）于20世纪70年代初首次被发现，此后一直是许多实验室的研究领域。VIP具有神经内分泌作用，因为它与其他神经内分泌激素以及细胞因子和趋化因子的合成、分泌和作用密切相关。VIP下调的主要后果包括发育和行为功能障碍，包括昼夜节律受损。VIP的过度表达与腹泻和癌症有关，而VIP受体的过度表达与癌性生长有关。这篇简短的综述概述了VIP研究中最近取得的一些进展。
