Keller Evan T, Murtha Jill M
Department of Urology, University of Michigan School of Medicine, 1500 E. Medical Ctr. Dr., Ann Arbor, MI 48109-0940, USA.
Comp Biochem Physiol C Toxicol Pharmacol. 2004 Jul;138(3):335-41. doi: 10.1016/j.cca.2004.04.001.
Zebrafish (Danio rerio) have been extensively utilized for understanding mechanisms of development. These studies have led to a wealth of resources including genetic tools, informational databases, and husbandry methods. In spite of all these resources, zebrafish have been underutilized for exploring pathophysiology of disease and the aging process. Zebrafish offer several advantages over mammalian models for these studies, including the ability to perform saturation mutagenesis and the capability to contain thousands of animals in a small space. In this review, we will discuss the use of mature zebrafish as an animal model and provide specific examples to support this novel use of zebrafish. Examples include demonstrating that clinical pathology can be performed in mature zebrafish and that age-associated changes in heat shock response can be observed in zebrafish. These highlights demonstrate the utility of zebrafish as a model for disease and aging.
斑马鱼（Danio rerio）已被广泛用于理解发育机制。这些研究催生了丰富的资源，包括遗传工具、信息数据库和饲养方法。尽管有这些资源，但斑马鱼在探索疾病病理生理学和衰老过程方面尚未得到充分利用。与哺乳动物模型相比，斑马鱼在这些研究中具有几个优势，包括能够进行饱和诱变以及在小空间内饲养数千只动物的能力。在这篇综述中，我们将讨论使用成熟斑马鱼作为动物模型，并提供具体例子来支持斑马鱼的这种新用途。例子包括证明可以在成熟斑马鱼中进行临床病理学研究，以及可以在斑马鱼中观察到热休克反应中与年龄相关的变化。这些亮点证明了斑马鱼作为疾病和衰老模型的实用性。
