Aleström Peter, Holter Jethro L, Nourizadeh-Lillabadi Rasoul
Department of Basic Sciences and Aquatic Medicine, Norwegian School of Veterinary Science, PO Box 8146 Dep, N-0033 Oslo, Norway.
Trends Biotechnol. 2006 Jan;24(1):15-21. doi: 10.1016/j.tibtech.2005.11.004. Epub 2005 Nov 23.
The zebrafish (Danio rerio) has many features that make it an ideal model for the study of developmental biology. It is small and easy to contain, it has transparent embryos, it is easy to breed and its early development is well characterized; these same characteristics have also made it an ideal vertebrate model in the areas of biomedicine and biotechnology. In aquaculture, the need for a well-characterized fish model has been satisfied by the zebrafish owing to the availability of functional genomics and molecular biology data to facilitate studies of growth, reproduction, meat quality and disease biology, with the corresponding development of vaccines and therapies. Zebrafish are also increasingly used in toxicogenomics to analyze the effects of toxins and pollutants in the environment, and for creating biomonitors that emit alarm signals when a toxic compound is detected. As detailed in this review, the zebrafish is a versatile and well-characterized model with applications in many fields of study.
斑马鱼（Danio rerio）具有许多特性，使其成为发育生物学研究的理想模型。它体型小，易于饲养，胚胎透明，易于繁殖，其早期发育特征明确；这些相同的特性也使其成为生物医学和生物技术领域理想的脊椎动物模型。在水产养殖中，由于有功能基因组学和分子生物学数据可用于促进对生长、繁殖、肉质和疾病生物学的研究，以及相应的疫苗和疗法的开发，斑马鱼满足了对特征明确的鱼类模型的需求。斑马鱼也越来越多地用于毒理基因组学，以分析环境中毒素和污染物的影响，并用于创建当检测到有毒化合物时发出警报信号的生物监测器。如本综述所述，斑马鱼是一种用途广泛且特征明确的模型，在许多研究领域都有应用。
