Cheesman Sarah E, Eisen Judith S
Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403-1254, USA.
Gene Expr Patterns. 2004 Nov;5(1):107-12. doi: 10.1016/j.modgep.2004.05.006.
We have cloned and characterized the expression of zebrafish genetic screen homeobox 1 (gsh1). Early expression is confined to hindbrain rhombomeres; by mid-somitogenesis gsh1 is expressed in precise domains within the mesencephalon and diencephalon, as well as in intermediate spinal cord. Double-label experiments revealed that the diencephalic domain is coincident with hypothalamus and that spinal cord expression is in a region that generates interneurons. These data suggest gsh1 may play a role in patterning cell types generated in these domains.
我们已经克隆并鉴定了斑马鱼遗传筛选同源盒1（gsh1）的表达。早期表达局限于后脑菱脑节；到体节形成中期，gsh1在中脑和间脑的特定区域以及脊髓中部表达。双标记实验表明，间脑区域与下丘脑重合，脊髓表达位于产生中间神经元的区域。这些数据表明gsh1可能在这些区域产生的细胞类型的模式形成中发挥作用。
