Strasser Andrew A, Pickworth Wallace B, Patterson Freda, Lerman Caryn
Transdisciplinary Tobacco Use Research Center, University of Pennsylvania, 3535 Market Street, Suite 4100, Philadelphia, PA 19104-3309, USA.
Cancer Epidemiol Biomarkers Prev. 2004 Nov;13(11 Pt 1):1800-4.
Smoking topography refers to how a person smokes a cigarette and includes measures of the number of puffs and puff volume, duration, and velocity. This study examined the relationship between smoking topography and abstinence from cigarettes following nicotine replacement therapy. A secondary objective was to determine the relationship of smoking topography to carbon monoxide (CO) exposure.
Participants (n = 113) smoked one of their preferred brands of cigarette through a smoking topography device prior to participating in an open-label trial of transdermal nicotine versus nicotine nasal spray. A subset of participants (n = 50) provided breath CO samples prior to and following smoking the cigarette.
Mean V(max) [odds ratio (OR), 1.12; 95% confidence interval (95% CI), 1.02-1.24; P = 0.02], mean puff volume (OR, 0.95; 95% CI, 0.91-0.98; P = 0.01), mean interpuff interval (OR, 1.06; 95% CI, 1.00-1.11; P = 0.03), and cigarette type (full flavor versus light/ultralight; OR, 0.35; 95% CI, 0.14-0.89; P = 0.03) were significant predictors of abstinence in a model controlling for treatment group and nicotine dependence. Controlling for time since last cigarette and initial CO level, mean puff velocity (beta = 0.171; P = 0.01) was the only significant predictor of CO boost.
These results suggest that smoking topography may be useful to predict abstinence after using nicotine replacement therapy and to assess harm from smoking.
吸烟特征是指一个人吸烟的方式，包括吸数、吸量、持续时间和速度等指标。本研究探讨了吸烟特征与尼古丁替代疗法后戒烟之间的关系。第二个目的是确定吸烟特征与一氧化碳（CO）暴露之间的关系。
参与者（n = 113）在参加透皮尼古丁与尼古丁鼻喷雾剂的开放标签试验之前，通过吸烟特征设备吸食其偏好品牌的香烟之一。一部分参与者（n = 50）在吸烟前后提供了呼出气体中的CO样本。
在控制治疗组和尼古丁依赖的模型中，平均最大吸速[比值比（OR），1.12；95%置信区间（95%CI），1.02 - 1.24；P = 0.02]、平均吸量（OR，0.95；95%CI，0.91 - 0.98；P = 0.01）、平均吸间间隔（OR，1.06；95%CI，1.00 - 1.11；P = 0.03）和香烟类型（全味型与淡味/超淡味型；OR，0.35；95%CI，0.14 - 0.89；P = 0.03）是戒烟的显著预测因素。在控制自上次吸烟后的时间和初始CO水平后，平均吸速（β = 0.171；P = 0.01）是CO升高的唯一显著预测因素。
这些结果表明，吸烟特征可能有助于预测使用尼古丁替代疗法后的戒烟情况以及评估吸烟危害。
