Woo Benjamin K P, Rice Valerie A, Legendre Susan A, Salmon David P, Jeste Dilip V, Sewell Daniel D
University of California, San Diego, CA, USA.
J Geriatr Psychiatry Neurol. 2004 Dec;17(4):190-4. doi: 10.1177/0891988704269820.
The aims of this research were to determine whether performance on the Clock Drawing Test (CDT) could accurately distinguish between older patients with depression and older patients with depression and previously undocumented executive dysfunction and to determine if there was a correlation between CDT and depression severity. The authors studied 52 patients consecutively admitted to a geriatric psychiatry inpatient unit of a university hospital who met DSM-IV criteria for major depression or depression not otherwise specified but had no concurrent diagnosis of dementia. All the subjects completed the Mini-Mental State Examination (MMSE), Mattis Dementia Rating Scale (DRS), and the CDT, as well as the Geriatric Depression Scale (GDS). The patients were divided into 2 subgroups based on the DRS score: <129 (cognitive impairment) versus = 129. Results indicated that the depressed patients with a score of DRS <129 had significantly lower CDT scores than did patients with DRS = 129 and normal comparison subjects (P< .01). The results support the hypothesis that CDT score is lower in elderly depressed patients with executive dysfunction versus nondepressed seniors as well as depressed patients without executive dysfunction.
本研究的目的是确定在画钟试验（CDT）中的表现是否能够准确区分老年抑郁症患者与患有抑郁症且此前未被记录有执行功能障碍的老年患者，并确定CDT与抑郁严重程度之间是否存在相关性。作者对连续入住某大学医院老年精神科住院部的52例患者进行了研究，这些患者符合DSM-IV中重度抑郁症或未另行规定的抑郁症标准，但未同时诊断为痴呆症。所有受试者均完成了简易精神状态检查表（MMSE）、马蒂斯痴呆评定量表（DRS）、CDT以及老年抑郁量表（GDS）。根据DRS评分将患者分为2个亚组：<129分（认知障碍）与=129分。结果表明，DRS评分<129分的抑郁症患者的CDT得分显著低于DRS=129分的患者及正常对照受试者（P<0.01）。结果支持以下假设：与无执行功能障碍的抑郁症患者以及无抑郁症的老年人相比，存在执行功能障碍的老年抑郁症患者的CDT得分更低。
