Gaffen Sarah L
Department of Oral Biology, School of Dental Medicine, University at Buffalo, State University of New York, USA.
Arthritis Res Ther. 2004;6(6):240-7. doi: 10.1186/ar1444. Epub 2004 Oct 8.
IL-17 and its receptor are founding members of an emerging family of cytokines and receptors with many unique characteristics. IL-17 is produced primarily by T cells, particularly those of the memory compartment. In contrast, IL-17 receptor is ubiquitously expressed, making nearly all cells potential targets of IL-17. Although it has only limited homology to other cytokines, IL-17 exhibits proinflammatory properties similar to those of tumor necrosis factor-alpha, particularly with respect to induction of other inflammatory effectors. In addition, IL-17 synergizes potently with other cytokines, placing it in the center of the inflammatory network. Strikingly, IL-17 has been associated with several bone pathologies, most notably rheumatoid arthritis.
白细胞介素-17（IL-17）及其受体是一个新兴的细胞因子和受体家族的创始成员，该家族具有许多独特特征。IL-17主要由T细胞产生，尤其是记忆细胞亚群中的T细胞。相比之下，IL-17受体在全身广泛表达，这使得几乎所有细胞都可能成为IL-17的作用靶点。尽管IL-17与其他细胞因子的同源性有限，但它具有与肿瘤坏死因子-α类似的促炎特性，特别是在诱导其他炎症效应因子方面。此外，IL-17能与其他细胞因子产生强大的协同作用，使其处于炎症网络的中心位置。值得注意的是，IL-17与多种骨骼疾病有关，最显著的是类风湿性关节炎。
