[严重急性呼吸综合征患者多器官功能障碍综合征的临床分析]
[Clinical analysis of multiple organ dysfunction syndrome in patients suffering from SARS].
作者信息
Yin Cheng-hong, Wang Chao, Tang Zhe, Wen Yan, Zhang Shu-wen, Wang Bao-en
机构信息
Beijing Friendship Hospital, Affiliated to Capital University of Medical Sciences, Beijing 100050, China.
出版信息
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2004 Nov;16(11):646-50.
OBJECTIVE
To analyze the features of organ dysfunction in severe acute respiratory syndrome (SARS) and the factors inducing multiple organ dysfunction syndrome (MODS) in these patients.
METHODS
The clinical data of 135 SARS patients and 13 patients with severe SARS complicated by MODS were studied retrospectively.
RESULTS
SARS could result in organ dysfunction. Its incidence rate was high, the patients' condition was severe, and the mortality was higher. SARS could end in MODS and the mortality was 92.3x. The main dysfunctioning organs were the lung (76.9x), the immune system (92.3x), the cardiovascular system (30.8x), the blood system (61.5x), the liver (38.5x), and the kidney (53.8x).
CONCLUSION
Dysfunction of organs are closely correlated with prognosis of SARS. The causes of MODS in SARS are probably injury to the immune system and systemic inflammatory response syndrome.
目的
分析严重急性呼吸综合征（SARS）患者器官功能障碍的特点以及导致这些患者发生多器官功能障碍综合征（MODS）的因素。
方法
回顾性研究135例SARS患者及13例合并MODS的重症SARS患者的临床资料。
结果
SARS可导致器官功能障碍。其发生率高，病情严重，死亡率较高。SARS可发展为MODS，死亡率为92.3%。主要功能障碍器官为肺（76.9%）、免疫系统（92.3%）、心血管系统（30.8%）、血液系统（61.5%）、肝脏（38.5%）和肾脏（53.8%）。
结论
器官功能障碍与SARS的预后密切相关。SARS患者发生MODS的原因可能是免疫系统损伤和全身炎症反应综合征。
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