Strickler J G, Singleton T P, Copenhaver C M, Erice A, Snover D C
Department of Pathology and Laboratory Medicine, University of Minnesota Hospitals, Minneapolis.
Am J Clin Pathol. 1992 Apr;97(4):555-8. doi: 10.1093/ajcp/97.4.555.
Adenovirus was cultured from various gastrointestinal sites and one lung specimen from seven immunosuppressed patients, four of whom were bone marrow transplant recipients. Histologic examination and in situ hybridization studies of the lung demonstrated adenovirus in the bronchial epithelium and alveolar lining cells. In contrast, none of the 34 gastrointestinal biopsies performed within 30 days of the positive adenovirus culture showed histologic or molecular evidence of invasive adenovirus in the gastrointestinal mucosa. These results suggest that isolation of adenovirus from gastrointestinal biopsy specimens taken from immunosuppressed patients probably does not indicate an invasive adenoviral infection.
从7名免疫抑制患者的不同胃肠道部位及1份肺标本中培养出腺病毒，其中4名患者为骨髓移植受者。对肺组织进行的组织学检查和原位杂交研究显示，支气管上皮和肺泡衬里细胞中有腺病毒。相比之下，在腺病毒培养阳性后的30天内进行的34次胃肠道活检中，没有一次显示胃肠道黏膜有侵袭性腺病毒的组织学或分子学证据。这些结果表明，从免疫抑制患者的胃肠道活检标本中分离出腺病毒可能并不表明存在侵袭性腺病毒感染。
