Watts Jo, Thomson Alex M
Department of Pharmacology, School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, UK.
J Physiol. 2005 Jan 1;562(Pt 1):89-97. doi: 10.1113/jphysiol.2004.076984. Epub 2004 Nov 11.
The cerebral cortex is pivotal in information processing and higher brain function and its laminar structure of six distinct layers, each in receipt of a different constellation of inputs, makes it important to identify connectivity patterns and distinctions between excitatory and inhibitory pathways. The 'feedforward' projections from layer 4-3 and from 3-5 target pyramidal cells and to lesser degrees interneurones. 'Feedback' projections from layer 5-3 and from 3-4, on the other hand, mainly target interneurones. Understanding the microcircuitry may give some insight into the computation and information processing performed in this brain region.
大脑皮层在信息处理和高级脑功能中起着关键作用，其具有六个不同层的分层结构，每层接收不同的输入组合，因此识别兴奋性和抑制性通路之间的连接模式和差异非常重要。从第4层到第3层以及从第3层到第5层的“前馈”投射以锥体细胞为目标，对中间神经元的作用程度较小。另一方面，从第5层到第3层以及从第3层到第4层的“反馈”投射主要以中间神经元为目标。了解微电路可能有助于深入了解该脑区所执行的计算和信息处理。
