Fayol L, Gulian J M, Dalmasso C, Calaf R, Simeoni U, Millet V
Département de Néonatologie, Assistance Publique, Hôpitaux de Marseille-Hôpital de La Timone, 264, rue Saint-Pierre, FR-13005 Marseille, France.
Biol Neonate. 2005;87(2):121-6. doi: 10.1159/000082128. Epub 2004 Nov 12.
To investigate the influence of maternal smoke exposure on neonatal and maternal antioxidant status, 39 mothers who were active smokers, 14 mothers exposed to environmental tobacco smoke (ETS), 17 controls, and their newborns were included in a prospective, controlled study. Plasma total antioxidant capacity, measured as total radical-trapping antioxidant parameter (TRAP) and ferric reducing antioxidant power (FRAP), and concentrations of specific antioxidants were measured in cord and in maternal blood. A similar, significant increase in ceruloplasmin concentration was observed in neonates born to actively smoking mothers and in those born to ETS exposed mothers. Uric acid and TRAP concentrations were significantly increased in ETS-exposed newborns and their mothers, compared to newborns and mothers from the active smoking and no-exposure groups with a trend towards increased uric acid, TRAP and FRAP concentrations being observed in the active smokers group. Neonatal and maternal antioxidant concentrations correlated significantly, except for ceruloplasmin. Cord blood vitamin A, E and C concentrations were unaffected by smoke exposure. These results show that maternal active smoking as well as ETS exposure significantly affect neonatal and maternal antioxidant status.
为研究母亲吸烟对新生儿及母亲抗氧化状态的影响，一项前瞻性对照研究纳入了39名主动吸烟的母亲、14名暴露于环境烟草烟雾（ETS）的母亲、17名对照母亲及其新生儿。测定了脐带血和母亲血液中的血浆总抗氧化能力，以总自由基捕获抗氧化参数（TRAP）和铁还原抗氧化能力（FRAP）衡量，以及特定抗氧化剂的浓度。在主动吸烟母亲所生新生儿和暴露于ETS母亲所生新生儿中，观察到铜蓝蛋白浓度有类似的显著升高。与主动吸烟组和无暴露组的新生儿及其母亲相比，暴露于ETS的新生儿及其母亲的尿酸和TRAP浓度显著升高，主动吸烟组的尿酸、TRAP和FRAP浓度有升高趋势。除铜蓝蛋白外，新生儿和母亲的抗氧化剂浓度显著相关。脐带血中维生素A、E和C的浓度不受烟雾暴露的影响。这些结果表明，母亲主动吸烟以及暴露于ETS会显著影响新生儿和母亲的抗氧化状态。
