Piastra Marco, Decarolis Maria Pia, Tempera Alessia, Caresta Elena, Polidori Giancarlo, Chiaretti Antonio, Pietrini Domenico, Ruggiero Antonio, Caldarelli Massimo, Di Rocco Concezio
Pediatric Intensive Care Unit, Catholic University Medical School, Rome, Italy.
J Pediatr Hematol Oncol. 2004 Nov;26(11):712-7. doi: 10.1097/00043426-200411000-00005.
Massive congenital intracranial teratoma is a rare neoplasm with a poor prognosis. Surgery may be curative only if complete resection can ben obtained. Several single case reports have been published in the pediatric literature, mostly focusing on prenatal diagnosis. The authors describe six patients with congenital intracranial teratoma treated at their institution in the past decade. Perioperatively, a marked hemostatic derangement was observed in three of them undergoing surgery: the pathophysiology of this complication is discussed. The surgical indication itself represents an ethical dilemma when treating a large intracranial tumor with partial destruction and replacement of brain structures.
巨大先天性颅内畸胎瘤是一种罕见的肿瘤，预后较差。只有在能够完全切除的情况下，手术才可能治愈。儿科文献中已发表了几例单病例报告，大多侧重于产前诊断。作者描述了过去十年在他们机构接受治疗的六例先天性颅内畸胎瘤患者。在围手术期，其中三名接受手术的患者出现了明显的止血紊乱：讨论了这种并发症的病理生理学。在治疗一个部分破坏并替代脑结构的大型颅内肿瘤时，手术指征本身就代表了一个伦理困境。
