真核生物中的核糖体RNA加工与核糖体生物合成
Ribosomal RNA processing and ribosome biogenesis in eukaryotes.
作者信息
Nazar Ross N
机构信息
Department of Molecular Biology and Genetics, University of Guelph, Guelph, Ontario, Canada.
出版信息
IUBMB Life. 2004 Aug;56(8):457-65. doi: 10.1080/15216540400010867.
PMID:15545225
Abstract
In eukaryotes nearly 500 rRNAs, ribosomal proteins, snoRNAs and trans-acting factors contribute to ribosome biogenesis. After more than 30 years of intense research, the incredible complexities of nucleolar function are revealed but details often remain unclear. Here we review this progress and the many intriguing questions which remain.
摘要
在真核生物中，近500种核糖体RNA、核糖体蛋白、核仁小RNA和反式作用因子参与核糖体的生物合成。经过30多年的深入研究，核仁功能令人难以置信的复杂性已被揭示，但细节往往仍不明确。在此，我们回顾这一进展以及众多仍有待解决的有趣问题。
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