喉/下咽癌器官保存方案后的听觉影响。

Auditory effects after organ preservation protocol for laryngeal/hypopharyngeal carcinomas.

作者信息

Liberman Patricia Helena Pecora, Schultz Christiane, Gomez M Valéria Schmidt Goffi, Carvalho André Lopes, Pellizzon Antonio Cassio Assis, Testa José Ricardo, Feher Olavo, Kowalski Luiz Paulo

机构信息

Department of Audiology, Hospital do Câncer A.C. Camargo, São Paulo, Brazil.

出版信息

Arch Otolaryngol Head Neck Surg. 2004 Nov;130(11):1265-8. doi: 10.1001/archotol.130.11.1265.

DOI:10.1001/archotol.130.11.1265

PMID:15545579

Abstract

OBJECTIVE

To investigate the prevalence of hearing loss after concomitant radiochemotherapy in patients enrolled in a larynx preservation protocol.

DESIGN

Prospective study.

SETTING

Consecutive patients treated in a tertiary cancer center hospital between 2001 and 2002.

PATIENTS

Eligible subjects included patients prospectively enrolled in an organ preservation protocol based on concomitant radiotherapy and chemotherapy (cisplatin and paclitaxel).

MAIN OUTCOME MEASURES

Descriptive analysis of the results of audiologic evaluations, including pure-tone audiometry and immitance audiometry, which were performed prior to and 8 months after treatment. Change in hearing sensitivity was computed relative to baseline measures. Criteria to indicate hearing decrease after the treatment were defined as either a 20-dB decrease at any single test frequency or a 10-dB decrease at any 2 adjacent test frequencies.

RESULTS

A total of 11 patients were analyzed. Four patients (36%) had hearing loss after the treatment.

CONCLUSION

Our results suggest that the prevalence of hearing loss after radiochemotherapy in larynx preservation protocols is high (36%); however, it was usually mild and asymptomatic.

摘要