Vicari Alain P, Trinchieri Giorgio
Schering-Plough Laboratory for Immunological Research, Dardilly, France.
Immunol Rev. 2004 Dec;202:223-36. doi: 10.1111/j.0105-2896.2004.00216.x.
Interleukin-10 (IL-10) is unique among cytokines, as it is considered both as a potent immunostimulatory and immunosuppressive factor. This complex biology has been particularly challenging when trying to define the useful or harmful role of IL-10 in chronic viral diseases and cancer. In the present review, we emphasize how these multiple roles define IL-10 as an adaptive molecule, constantly tuning the host response against dangerous and resourceful pathogens.
白细胞介素-10（IL-10）在细胞因子中独具特色，因为它既被视为一种强大的免疫刺激因子，又被看作免疫抑制因子。在试图界定IL-10在慢性病毒性疾病和癌症中有益或有害作用时，这种复杂的生物学特性尤其具有挑战性。在本综述中，我们着重阐述这些多重作用如何将IL-10定义为一种适应性分子，不断调节宿主针对危险且足智多谋的病原体的反应。
