Schlitt Axel, Hojjati Mohammad R, von Gizycki Hans, Lackner Karl J, Blankenberg Stefan, Schwaab Bernhard, Meyer Juergen, Rupprecht Hans J, Jiang Xian-Cheng
Department of Anatomy and Cell Biology and Scientific Computing Center, State University of New York, Downstate Medical Center, Brooklyn, NY, USA.
J Lipid Res. 2005 Feb;46(2):196-200. doi: 10.1194/jlr.C400011-JLR200. Epub 2004 Nov 16.
It is known that sphingomyelin (SM) content is higher in apolipoprotein B-containing particles (BLps) than in high density lipoproteins and that BLp levels, including chylomicrons and their remnant particles, are positively related to atherosclerosis. To evaluate the relationship between serum SM and postprandial remnant particle levels, we determined SM, triglyceride (TG), and cholesterol levels in serum and in remnant-like particles (RLPs) before and 3, 5, 7, and 10 h after a high-fat meal in 31 healthy subjects. We found that serum SM, like serum TG, was increased to its maximum 3 h after fat loading and then gradually decreased to basal levels after 10 h. More important, we determined that SM and TG levels in RLPs were parallel. Serum SM was positively correlated with serum TG (P <0.001), RLP SM (P <0.001), RLP TG (P <0.001), and RLP cholesterol (P <0.001) levels. It is our conclusion that serum SM is a marker for the clearance of RLPs.
已知含载脂蛋白B的颗粒（BLps）中的鞘磷脂（SM）含量高于高密度脂蛋白，且包括乳糜微粒及其残余颗粒在内的BLp水平与动脉粥样硬化呈正相关。为评估血清SM与餐后残余颗粒水平之间的关系，我们测定了31名健康受试者在高脂餐后0、3、5、7和10小时血清及残余样颗粒（RLPs）中的SM、甘油三酯（TG）和胆固醇水平。我们发现，血清SM与血清TG一样，在脂肪负荷后3小时升高至最大值，然后在10小时后逐渐降至基础水平。更重要的是，我们确定RLPs中的SM和TG水平呈平行关系。血清SM与血清TG（P<0.001）、RLP SM（P<0.001）、RLP TG（P<0.001）和RLP胆固醇（P<0.001）水平呈正相关。我们的结论是，血清SM是RLPs清除的标志物。
