Matsumoto Kakuya, Mizoshita Tsutomu, Tsukamoto Tetsuya, Ogasawara Naotaka, Hirata Akihiro, Shimizu Yasuhiro, Haneda Masakazu, Yamao Kenji, Tatematsu Masae
Division of Oncological Pathology, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan.
Oncol Rep. 2004 Dec;12(6):1239-43.
We have previously reported that Caudal-related homeobox gene 2 (Cdx2) is a useful prognostic intestinal phenotypic marker for advanced gastric cancers. In this study, we examined Cdx2 expression and phenotype in pancreatic tumors. We evaluated 19 mucinous cystic tumors (MCTs), 17 intraductal papillary-mucinous tumors (IPMTs), and 41 invasive ductal carcinomas (IDCs) with regard to their gastrointestinal phenotype. The expression of Cdx2 was also assessed immunohistochemically. The lesions were phenotypically divided into 39 gastric (G type), 29 gastric and intestinal mixed (GI type), 3 intestinal (I type), and 6 null (N type) types, independent of the histopathological type. Most of the pancreatic tumors were thus judged to be the positive for gastric phenotypic members. Cdx2 nuclear staining demonstrated a close relation to the intestinal phenotypic expression in all three types (MCTs, IPMTs, and IDCs; p<0.05). In IDCs, Kaplan-Meier analysis of Cdx2 expression showed the Cdx2-positive group to have a significantly better outcome than their negative counterparts (p=0.015). In conclusion, our data suggest that Cdx2 might be necessary for intestinal phenotypic expression even in pancreatic tumor cells. In addition, Cdx2 expression in IDCs may be a novel prognostic marker for patient survival.
我们之前曾报道，尾型相关同源盒基因2（Cdx2）是晚期胃癌一种有用的预后肠道表型标志物。在本研究中，我们检测了胰腺肿瘤中Cdx2的表达及表型。我们评估了19例黏液性囊性肿瘤（MCT）、17例导管内乳头状黏液性肿瘤（IPMT）以及41例浸润性导管癌（IDC）的胃肠道表型。还通过免疫组织化学方法评估了Cdx2的表达。这些病变在表型上分为39例胃型（G型）、29例胃和肠混合型（GI型）、3例肠型（I型）以及6例无表达型（N型），与组织病理学类型无关。因此，大多数胰腺肿瘤被判定为胃表型成员阳性。Cdx2核染色在所有三种类型（MCT、IPMT和IDC）中均显示与肠道表型表达密切相关（p<0.05）。在IDC中，对Cdx2表达的Kaplan-Meier分析显示，Cdx2阳性组的预后明显优于阴性组（p=0.015）。总之，我们的数据表明，即使在胰腺肿瘤细胞中，Cdx2可能也是肠道表型表达所必需的。此外，IDC中Cdx2的表达可能是患者生存的一种新的预后标志物。
